Sample size in clinical research: when is enough enough?
نویسنده
چکیده
منابع مشابه
Determination of sample size in genome-scale RNAi screens
MOTIVATION For genome-scale RNAi research, it is critical to investigate sample size required for the achievement of reasonably low false negative rate (FNR) and false positive rate. RESULTS The analysis in this article reveals that current design of sample size contributes to the occurrence of low signal-to-noise ratio in genome-scale RNAi projects. The analysis suggests that (i) an arrangem...
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One of the most common questions asked of statisticians is, “How many are enough?” The answer to that question, unfortunately, is complex, and only part of it can be answered by the statistician. This is because power calculation is part mathematical calculation and part judgment call. The former requires knowledge about population characteristics; the latter requires choices about tolerable er...
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SAMPLE SIZE MUST BE PLANNED carefully to ensure that the research time, patient effort and support costs invested in any clinical trial are not wasted. Item 7 of the CONSORT statement relates to the sample size and stopping rules of studies (see Box 1); it states that the choice of sample size needs to be justified. 1 Ideally, clinical trials should be large enough to detect reliably the smalle...
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عنوان ژورنال:
- Journal of personality assessment
دوره 87 3 شماره
صفحات -
تاریخ انتشار 2006